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Herpes Immune SystemPosted on April 4, 2010. Having genital herpes weaken your immune system? Making you more susceptible to colds and sore throats, even if genital herpes outbreaks are not present? Not at all! If your immune system is weak, it can make you get a herpes outbreak, herpes but has no effect on your immune system. CommentsThere are no comments.Leave a Comment | Popular My Friends |